Characteristics of new coronavirus infection in patients with acute myeloid leukemia

Authors / Institutions

Dmitry O. Ivanov / St.Petersburg State Paediatric Medical University, St.Petersburg, Russian Federation

Yury V. Petrenko / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Vitaly A. Reznik / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Ruslan A. Nasyrov / St.Petersburg State Paediatric Medical University, St.Petersburg, Russian Federation

Vladimir N. Timchenko / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Maria D. Subbotina / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Tatyana M. Chernova / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Svetlana L. Bannova / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Gleb V. Kondratyev / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Olga L. Krasnogorskaya / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Moisei B. Paneakh / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Elena P. Fedotova / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Tatyana A. Kaplina / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

Maria A. Shakmaeva / Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

In the Russian Federation, the proportion of children among all cases of new coronavirus infection is up to 8.6%. Mild forms are registered in 80% of cases, severe – 0.2%, as a rule, in children of the first year of life. The majority of deaths were recorded in children with an unfavorable background: 75% of those who died had one concomitant pathology, 45% – two or more. The problem of severe course and fatal outcomes from COVID-19 in children with comorbid pathology, for example, with various forms of leukemia, remains relevant. Severe infectious complications of bacterial nature are observed in 70–80% of sick children, viral and fungal genesis, respectively, in 4–12% and 18–20%. Myeloblastic leukemia is one of the factors that predispose to a severe course of COVID-19 and an unfavorable outcome. The article presents a clinical observation of the course of a critical form of a new coronavirus infection in a young child with acute myeloblastic leukemia. The layering of COVID-19 contributed to a sharp deterioration of the underlying disease. Despite the highly organized treatment process with the use of modern technologies, the child had a rapid deterioration of the condition with a fatal outcome.
Key words: COVID-19, children, acute myeloblastic leukemia, pancytopenia, fatal outcome
For citation: Ivanov D.O., Petrenko Yu.V., Reznik V.A., Nasyrov R.A., Timchenko V.N., Subbotina M.D., Chernova T.M., Bannova S.L., Kondratyev G.V., Krasnogorskaya O.L., Paneakh M.B., Fedotova E.P., Kaplina T.A., Shakmaeva M.A. Characteristics of new coronavirus infection in patients with acute myeloid leukemia. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2021; 16(3): 121–129. (In Russian). DOI: 10.20953/1817-7646-2021-3-121-129